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. 2011 May 15;20(16):3161–3175. doi: 10.1093/hmg/ddr218

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© The Author 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Restoration of cone-mediated ERG in Cngb3^−/− mice treated at different ages. Data are represented as means ± SEM of photopic b-wave ERG recordings done at.10 cd.s/m² measured at ca 3–4 months post-injection. Treated and untreated n for each group was as follows: P6 = 6; P15 = 6; P30 = 11; P90 = 9; P180 = 6. Wild-type measurements were from 5 to 7 animals. Paired Student's t-test was used to determine significance between treated and untreated eyes in all age groups; all showed significance (P-values as follows: P6, P= 0.045; P15, P= 0.0017; P30, P= 9 × 10⁻⁶; P90, P= 0.0006; P180, P= 0.0024. Unpaired Student's t-test was used to determine significance between treated and wild-type eyes; only the P6 and P180 groups were significantly different (*P= 0.0017; **P= 0.0259).