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Brain hemorrhage in inducibly deleted, adult Ccm2 mutant mice. Gross view and coronal sections are shown. Brain lesions are detected in the cerebrum and cerebellum of 7–8 months-old, polyinosinic–polycytidylic acid (pIpC)-treated Ccm2flox/flox;MX1-Cre mice (B, D, F, H), but not in similarly treated Ccm2flox/+;MX1-Cre control littermates (A, C, E, G). Scale bars are 1 mm.
