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. Author manuscript; available in PMC: 2012 Jun 10.
Published in final edited form as: Circ Res. 2011 Apr 28;108(12):1448–1458. doi: 10.1161/CIRCRESAHA.111.241117

Figure 4.

Figure 4

VE training increased the circulating and myocardial levels of NO metabolites. Levels of nitrite, nitrate, and nitrosothiols (RXNO and RSNO) were measured in the (A–C) plasma and (D–F) heart following 4 weeks of VE training. (G) Mice deficient in eNOS (eNOS−/−) were subjected to 4 weeks of VE training and then to 45 min of left coronary artery occlusion followed by reperfusion. Myocardial AAR/LV, INF/AAR, and INF/LV were then evaluated at 24 hours of reperfusion. Steady-state levels of plasma (H) nitrite, nitrate, and (I) nitrosothiol levels in individuals who exercised for at least 45 minutes a day, 3 times a week for at least 2 years (trained endurance athletes) and from non-trained individuals. Values are means ± S.E.M. *p<0.05, **p<0.01, and ***p<0.001 vs. SED.