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. Author manuscript; available in PMC: 2011 Jul 21.
Published in final edited form as: Angiogenesis. 2010 Apr 22;13(2):189–202. doi: 10.1007/s10456-010-9166-0

Fig. 6.

Fig. 6

MR signal enhancement up to 8-week post-treatment with targeted fumagillin nanoparticles and/or oral atorvastatin. Top: Untreated and statin treated animals showed a constant level of angiogenesis in the aortic wall. Animals treated with targeted fumagillin nanoparticles at weeks 0 and 4 showed decreased angiogenesis (* P < 0.05) following each dose, which returned to baseline levels within 4 weeks. Bottom: The combination of two fumagillin doses and statin produced a sustained decrease in angiogenesis (* P < 0.05). Green arrow points to synergistic suppression of angiogenesis not achieved with statin or fumagillin alone (see top panel). Reproduced with permission [64]