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. 2011 Jun 16;3:551–564. doi: 10.1093/gbe/evr056

FIG. 3.

FIG. 3.

Summary of previous studies showing the different functional properties of C-terminal isoforms. (A) Differences in activity as transcriptional activators between C-terminal isoforms within each paralogous Meis gene in mammals. Top: histogram showing the ratio for activity of B (excluding 12a) versus A (including 12a) isoforms. Data for Meis1 correspond to a protein fusion of the activation domain (AD, C-terminus) from each of the isoforms. Meis2 data correspond to comparisons of full-length proteins and averaging the values for isoforms derived of inclusion/exclusion of exon 11′. Bottom: table summarizing the phenotypic results after injecting two different concentrations of full-length Meis1A or Meis1B isoforms in Xenopus embryos. Note that the intensity of the effect is not only isoform dependent but also concentration dependent. (B) Different C-terminal isoforms have different responses to TSA treatment. Histogram showing the fold-increase in transcriptional activation after TSA treatment for each Meis1 isoform, Meis2A.2 (excluding 11′ but including 12a) and the related pknox1 gene. References: (1) Huang et al. (2005), (2) Yang et al. (2000), (3) Maeda et al. (2001), and (4) Shim et al. (2007).