Table 1.

Association between c-fos in CNS and clinical parameters of IBS model

		c-fos in frontal lobe	c-fos in hippocampus	c-fos in cornu dorsale
Body weight gain	R	−0.763	−0.958	−0.929
	P value	0.017	0.000	0.000
Colonic motility	R	0.831	0.656	0.725
	P value	0.005	0.055	0.027
Visceral sensation (0 ml)	R	0.823	0.776	0.706
	P value	0,006	0.014	0.034
Visceral sensation (0.4 ml)	R	0.916	0.848	0.788
	P value	0.001	0.004	0.012
Visceral sensation (0.8 ml)	R	0.755	0.856	0.823
	P value	0.019	0.003	0.006
Visceral sensation (1.2 ml)	R	0.857	0.716	0.723
	P value	0.003	0.030	0.028

Association between c-fos in CNS (frontal lobe, hippocampus, and cornu dorsale) and clinical parameters (general state, colonic motility, visceral sensation) was analyzed using Pearson’s correlation test in IBS model rats(n = 30). c-fos in CNS significantly correlated with the clinical parameters (P < 0.05)

r Pearson correlation coefficient