Table 1. Percentages of conformational transitions between open and closed states for KD-AID and Mutants.

Protein	Start State	Total # Trajectories	No transition	Transition
KD-AID	Open	90	100%	0%
KD-AID Mutant 1	Open	90	100%	0%
KD-AID Mutant 2	Open	90	92%	8%
KD-AID Mutant 2	Closed	70	83%	17%
KD-AID Mutant 3	Open	90	97%	3%
KD-AID Mutant 3	Closed	70	70%	30%
KD fragment	Open	70	80%	20%
KD fragment	Closed	70	91%	9%

Rows represent the different start states, open (3H4J) or closed (3DAE), for each protein (if accessible), the total number of 10 ns simulations starting from that configuration, and the percentage of observed outcomes that classify the final structure as open or closed.