Figure 2. MTB proteins categorized by their functions and their level of specificity.

MTB proteins categorized by their functions and their level of specificity. Specificity was defined based on the similarity searches in other, bacterial and eukaryotic proteomes. Proteins that do not show significant similarity to any proteins outside the MTB or M. bovis proteomes are considered “MTB specific” (purple), proteins with homologs in other mycobaceria, other bacteria are labeled accordingly (blue and green bars). Ubiquitous proteins with homologues in all kingdoms of life are shown with orange bars. As both functional categories and specificity levels are mutually exclusive, the sum of all bars is equal to the total number of MTB proteins. Functional categories are numbered as follows: 1 – virulence, detoxification, adaptation; 2 – lipid metabolism; 3 – information pathways; 4 – cell wall and cell processes; 5 – insertion sequences and phages; 6 – PE/PPE; 7 – intermediary metabolism and respiration; 8 – regulatory proteins; 9 – conserved hypotheticals.