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. 2011 Jul 21;6(7):e21782. doi: 10.1371/journal.pone.0021782

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Malashchenko et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The increase of the half-inactivation voltage of the slow calcium current, shifts towards more hyperpolarized values of changing the activity from tonic spiking (A) to bursting (B–D). (A) For = 0.047 V the model exhibits a periodic tonic spiking activity. (B–D) The increase of up to 0.048 V shifts towards the hyperpolarized value of thus changing the activity from tonic spiking to bursting. (C) The increase of to 0.056 V expands the interburst interval. (D) = 0.06 V brings the value of the interburst interval close to the targeted value. The leak current parameters are the same as in Fig. 1. was 0.031 V for A and D. Panels (B)–(D) have the same time scale.

Inline graphic — The increase of the half-inactivation voltage of the slow calcium current, shifts towards more hyperpolarized values of changing the activity from tonic spiking (A) to bursting (B–D). (A) For = 0.047 V the model exhibits a periodic tonic spiking activity. (B–D) The increase of up to 0.048 V shifts towards the hyperpolarized value of thus changing the activity from tonic spiking to bursting. (C) The increase of to 0.056 V expands the interburst interval. (D) = 0.06 V brings the value of the interburst interval close to the targeted value. The leak current parameters are the same as in Fig. 1. was 0.031 V for A and D. Panels (B)–(D) have the same time scale.