Figure 6. Potent antitumor activity on hepatocellular carcinoma xenografts with SG7011^let7T.

(A) Measurement of antitumor activity. BALB/c nude mice (n = 10 per group) bearing Hep3B or SMMC-7721 xenografts were treated with WAd5, SG7011^let7T, and virus preservation buffer control by i.t. administration five times at a dosing volume of 100 µl (5×10⁸ pfu), on the days of 1, 3, 5, 7 and 9 following the initiation. Tumor volume was estimated with the formula: (maximal diameter)×(perpendicular diameter) 2×0.5. Error bars correspond to mean ± SD. (B) Pathologic examination of Hep3B or SMMC-7721 tumor xenografts. The necrosis areas in HE staining was indicated by thin arrow and the area showing positive signal in immunohistochemistry staining with anti-hexon antibodies was indicated by bold arrow. (×400) Let7T, SG7011^let7T.