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. 2011 Jul 21;7(7):e1002160. doi: 10.1371/journal.pgen.1002160

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Perfeito et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The fitness cost of the lac pathway is shown as a function of the operator genotype summary variable (maximum rate of protein production at a growth of 1 cell division/hr, see text) and the external inducer concentration . The model fitness landscape is again strongly nonlinear: it has a stable upper branch (solid shading) and an unstable lower branch (striped shading) separated by a fitness cliff (blue line), similar to the phenotype-fitness map of Figure 4. Model predictions for individual strains under varying inducer concentrations are shown as a family of red lines (light red: wild type; dark red: operator mutant strains with equal to wild type value, see text). Experimental fitness values are shown as dots (the offset from the model surface is marked by gray lines).

Inline graphic — The fitness cost of the lac pathway is shown as a function of the operator genotype summary variable (maximum rate of protein production at a growth of 1 cell division/hr, see text) and the external inducer concentration . The model fitness landscape is again strongly nonlinear: it has a stable upper branch (solid shading) and an unstable lower branch (striped shading) separated by a fitness cliff (blue line), similar to the phenotype-fitness map of Figure 4. Model predictions for individual strains under varying inducer concentrations are shown as a family of red lines (light red: wild type; dark red: operator mutant strains with equal to wild type value, see text). Experimental fitness values are shown as dots (the offset from the model surface is marked by gray lines).