Figure 2. The neuron-selective increase in NSM or ADF serotonergic signaling by RNAi knockdown of mod-5 that encodes a 5-HT reuptake transporter differentially modulates aversive responses.

Wild-type, mutant, transgenic and RNAi expressing animals were examined for aversive responses to dilute 1-octanol (30%) in the presence or absence of food and/or 5-HT (4 mM), as described in Methods. Data are presented as a mean ± SE and analyzed by two-tailed Student's t test. “*” P<0.001, significantly different from wild-type animals incubated in the presence of food.