Table 1. Comparison of vestibular features according to the genotypes and the circling behavior.
Slc26a4+/+ | Slc26a4+/tm1Dontuh | Slc26a4tm1Dontuh/tm1Dontuh | Slc26a4tm1Dontuh/tm1Dontuh | |
(n = 15) | (n = 15) | (Non-circling) | (Circling) | |
(n = 15) | (n = 15) | |||
Head tilting* (n, abnormal/total) | 0/15 | 0/15 | 0/15†, | 15/15‡ |
Reaching§ (n, abnormal/total) | 0/15 | 0/15 | 4/15† | 11/15‡ |
Swimming§ (n, abnormal/total) | 0/15 | 0/15 | 2/15† | 11/15‡ |
Gripping§ (n, abnormal/total) | 0/15 | 0/15 | 3/15† | 13/15‡ |
Time on rod§ (sec) | 164.7±13.9 | 159.3±18.1 | 66.3±8.9‡ | 4.0±1.6‡ |
*Observed at 3 weeks.
Tested at 8 weeks.
p>0.05 as compared to wild type.
p<0.01 as compared to wild type.