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A) SceOSC active site (in green) and lanosterol location (in yellow) as deduced from HsaOSC crystallographic data (1W6K). B) Aas involved in the channel constriction (in pink) as suggested by SHC-based considerations. C) Aas involved in the channel constriction (in orange) as suggested HsaOSC-based considerations. D) Mutated residues studied in this work (together with Glu526 shown for comparison).
