Table 1. Sulfur metabolism genes from M. tuberculosis induced by various conditions of environmental stress.
Stress Condition | Genes Induced | Reference |
5-Chloropyrazinamide | cysN | [20] |
Hydrogen peroxide | cysD, cysNC a, cysK2, cysM, cysT | [21], [22] |
Hypoxia | cysD, cysK2, cysN, cysM | [23], [24] |
Macrophage infection | cysD, cysN | [21], [25] |
Menadione | cysA1, cysT, cysW, subI | [20] |
Nutrient starvation | cysA1, cysD, cysH, cysN, cysQ, cysT, cysW, sirA, subI | [26], [27] |
SDS | cysD, cysN | [28] |
Vancomycin | cysD, cysK2, cysNC | [29] |
The cysN and cysC genes of Mtb are fused into a single, bifunctional cysNC gene [22]. However, the transcript is often reported as cysN in microarray data.
SDS, sodium dodecyl sulfate.