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. 2011 Jul 21;6(7):e22567. doi: 10.1371/journal.pone.0022567

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Caillou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Original magnification: ×200. Cluster of CD163-positive RTAMs closely surround large blood vessel (B.V.) and small capillary (cap) and “stick together”. From this cluster, interconnected chains of RTAMs extend to within the tumor. Connections between RTAMs and cancer cells can be thick or very thin. (Long arrows show thin connections between RTAMS. Arrowheads show thin connections between RTAMs and cancer cells).