Table 1.
Participant characteristics
| Motor Level and Completeness of Injury |
||||
|---|---|---|---|---|
| Motor Complete and AIS C Tetraplegia |
Motor Complete and AIS C Paraplegia |
All AIS D | Total | |
| Patients, n | 9 (15.2%) | 19 (32.2%) | 31 (52.5%) | 59 |
| Age, y | 51.8 [10.0] | 52.0 [15.1] | 60.1 [15.3] | 56.2 [14.9] |
| Years since injury | 26.3 [8.5] | 20.4 [10.7] | 19.6 [14.5] | 20.9 [12.6] |
| Stature, cm | 174.2 [6.3] | 172.3 [8.1] | 175.8 [6.7] | 174.5 [7.2] |
| Weight, lb | 174 [22.4] | 178.6 [33.4] | 192.1 [39.5] | 185.0 [35.8] |
| BMI | ||||
| Normal (18.5 to <25 kg/m2) | 5 (55.6%) | 7 (36.8%) | 11 (35.5%) | 23 (39.0%) |
| Overweight (25 to <30 kg/m2) | 3 (33.3%) | 6 (31.6%) | 9 (29.0%) | 18 (30.5%) |
| Obese (≥30 kg/m2) | 1 (11.1%) | 6 (31.6%) | 11 (35.5%) | 18 (30.5%) |
| Smoking | ||||
| Current | 1 (11.1%) | 2 (10.5%) | 6 (19.4%) | 9 (15.3%) |
| Former | 5 (55.6%) | 6 (31.6%) | 16 (51.6%) | 27 (45.8%) |
| Never | 3 (33.3%) | 11 (57.9%) | 9 (29.0%) | 23 (39.0%) |
| No. pack years (in ever smokers) | 11.6 [9.8] | 32.2 [33.8] | 31.0 [22.1] | 28.1 [24.3] |
| Heart disease | 2 (22.2%) | 2 (10.5%) | 6 (19.4%) | 10 (17.0%) |
| Hypertension | 1 (11.1%) | 5 (26.3%) | 9 (29.0%) | 15 (25.4%) |
| Diabetes | 0 (0.0%) | 3 (15.8%) | 6 (19.4%) | 9 (15.3%) |
| COPD | 0 (0.0%) | 3 (15.8%) | 3 (9.7%) | 6 (10.2%) |
| Asthma | 1 (11.1%) | 4 (21.1%) | 3 (9.7%) | 8 (13.6%) |
| COPD or asthma | 1 (11.1%) | 5 (26.3%) | 5 (16.1%) | 11 (18.6%) |
| FEV1, L | 2.7 [0.5] | 3.1 [1.0] | 2.9 [1.0] | 2.9 [0.9] |
| FVC, L | 3.4 [0.7] | 3.9 [1.0] | 3.7 [1.1] | 3.7 [1.0] |
| FEV1/FVC, % | 81.2 [9.0] | 79.6 [11.6] | 76.0 [8.2] | 78.0 [9.6] |
| %-Predicted FEV1 | 74.2 [15.0] | 87.9 [24.2] | 82.4 [20.1] | 82.9 [21.0] |
| %-Predicted FVC | 71.1 [15.0] | 84.3 [20.6] | 82.0 [19.2] | 81.1 [19.3] |
| Inflammatory markers, median [25th-75th percentile] |
||||
| CRP, mg/L | 1.8 [1.0-5.3] | 2.0 [0.7-4.7] | 1.4 [1.0-3.6] | 1.8 [1.0-4.0] |
| IL-6, pg/mL | 2.0 [1.3-4.6] | 2.0 [1.1-4.4] | 2.2 [1.3-4.3] | 2.1 [1.3- 4.4] |
Values are expressed as mean [SD] unless otherwise indicated.
AIS = American Spinal Injury Association Impairment Scale; AIS C = most key muscles grade <2/5 below the neurologic level; AIS D = most muscles are ≥3/5; BMI = body mass index; COPD = chronic obstructive pulmonary disease; L = liters; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; CRP = C-reactive protein; IL-6 = interleukin-6.