Table 2.
IL-6 in quartiles (Q) and pulmonary function
| Mean %- predicted FEV1, adjusted for each factor listed | ||||
|---|---|---|---|---|
| IL-6, pg/mL | Unadjusted | COPD | SCI level and completeness | Pack years, BMI |
| P for trend | <.001 | .002 | <.001 | .014 |
| Q 1 (≥4.4) | 69.8 | 66.9 | 69.0 | 74.1 |
| Q 2 (2.1 to <4.4) | 78.3 | 74.5 | 76.0 | 78.7 |
| Q 3 (1.3 to <2.1) | 91.1 | 86.0 | 89.9 | 90.6 |
| Q 4 (<1.3) | 92.4 | 88.0 | 90.7 | 89.4 |
| Mean %- predicted FVC, adjusted for each factor listed | ||||
|---|---|---|---|---|
| IL-6, pg/mL | Unadjusted | COPD | SCI level and completeness | Pack years, BMI |
| P for trend | .006 | .010 | .007 | .039 |
| Q 1 (≥4.4) | 71.5 | 70.8 | 70.1 | 74.5 |
| Q 2 (2.1 to <4.4) | 75.6 | 74.7 | 72.3 | 75.4 |
| Q 3 (1.3 to <2.1) | 90.4 | 89.2 | 88.8 | 91.1 |
| Q 4 (<1.3) | 86.9 | 85.8 | 84.5 | 84.8 |
| Mean FEV1/FVC, adjusted for each factor listed | ||||
|---|---|---|---|---|
| IL-6, pg/mL | Unadjusted | COPD | Age, SCI level and completeness | Age, pack years, BMI |
| P for trend | .004 | .013 | .039 | .123 |
| Q 1 (≥4.4) | 72.9 | 69.9 | 74.5 | 74.7 |
| Q 2 (2.1 to <4.4) | 77.5 | 73.6 | 79.5 | 78.9 |
| Q 3 (1.3 to <2.1) | 77.9 | 72.7 | 78.0 | 76.4 |
| Q 4 (<1.3) | 83.6 | 79.1 | 82.7 | 81.2 |
IL-6 = interleukin-6; FEV1 = forced expiratory volume in 1 second; COPD = chronic obstructive pulmonary disease; SCI = spinal cord injury; BMI = body mass index; FVC = forced vital capacity.