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Observed isoniazid concentrations plotted against time after dose, obtained from patients at DP Marais SANTA Centre (DPM) and Brewelskloof Hospital (BKH). Dosing was 5 days per week, Monday to Friday, at DPM, and daily at BKH, owing to policy differences between the sites. Time points for 200 mg and 450 mg doses in the BKH plot have been jittered by 0.25 h to facilitate visibility
