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| Segment | Mutation | Function |
|---|---|---|
| 1(PB2) | D701N | Increased host range, polymerase activity, and pathogenicity |
| E627K | Increased virulence | |
| 4(HA) | D190E | Both involved in host receptor specificity for the α2-3 and |
| D222G/E | α2-6 sialic acid receptors | |
| 5(NP) | V100I | Increased transmissibility or infectivity |
| 6(NA) | I223V | Decreased neuraminidase inhibitor sensitivities |
| H274Y | Oseltamivir resistance | |
| 7(M2) | S31N | Adamantine resistance |
