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. 2011 Mar 18;39(13):5388–5400. doi: 10.1093/nar/gkr108

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Allele-specific methylation at the FAM50B locus. (A) Clones obtained from bisulfite-treated conceptus liver DNA are either predominantly methylated or unmethylated from the 18th CpG site to the 66th CpG site. (B) Clones obtained from bisulfite-treated conceptus liver DNA, representing one of three individuals heterozygous for SNP rs2239713 (arrow), while their matched maternal deciduae are homozygous G/G for the SNP sites. The allele-specific distribution of methylation with respect to the G/A polymorphism demonstrates that the maternally-derived allele is methylated while the paternally derived allele is unmethylated. (C) Clones obtained from bisulfite-treated mature sperm DNA are completely unmethylated. CpG sites are represented by circles. Unfilled circle, unmethylated CpG site; filled circle, methylated CpG site.