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. 2011 Mar 16;39(13):5647–5657. doi: 10.1093/nar/gkr145

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Depletion of PABP-2 has only minor effects on translation efficiency. (A) Typical polysome profiles of let-7(n2853) animals grown on mock(RNAi) or pabp-2(RNAi). Fractions 1–5 comprise the (sub)-monosome, fractions 6–12 the polysomes. (B) RNAi against pab-1, the C. elegans orthologue of the human or yeast cytoplasmic (type I) poly(A)-binding protein restrains translation. (C and D) Polysomal fractions of mRNAs are plotted as percentage of the total (=monosomal + polysomal fractions) in late L4 wild-type (C) and let-7(n2853) (D) animals grown on either mock(RNAi) or pabp-2(RNAi). Numbers are the averages of ≥3 independent experiments. Error bars represent SEM.