Table 1.
Number of genes in each subfamily per species/clades
| M | R/B | X | F | Ci | Su | I | W | Fu | Mo | Sm | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RAPGAP | |||||||||||
| TSC2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 |
| GARNL1 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
| SIPA1 | 4 | 4 | 1 | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| RAP1GAP | 2 | 2 | 1 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
| GARNL3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
| RASGAP | |||||||||||
| IQGAP | 3 | 3 | 3 | 3 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
| NF1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
| RASA | 4 | 4 | 3 | 4 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
| SYNGAP | 4 | 4 | 1 | 4 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| RASA1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| GAPVD1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| RASGEF | |||||||||||
| PLCE1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
| RASGRF | 2 | 2 | 2 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| KNDC1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| RASGEF1 | 3 | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 0 |
| RAPGEF1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| RGL | 5 | 4 | 3 | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| RALGPS | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| RAPGEF2/6 | 2 | 2 | 1 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
| RAPGEF3/4 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| RAPGEF5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RAPGEFL1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RASGRP | 4 | 4 | 4 | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
| SOS | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 0 |
| RAS | |||||||||||
| RASL10 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| RASD | 2 | 2 | 2 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| SSR2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 |
| NKIRAS | 2 | 2 | 2 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| REM | 4 | 4 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| RGK | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 |
| RASL11 | 2 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RERG | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| RASL12 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| AGAP | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| RERGL | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RHEB | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| ERAS | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RAL | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 0 |
| RAP1 | 2 | 2 | 2 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| RAP2 | 3 | 3 | 3 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| H/K/NRAS | 3 | 3 | 3 | 3 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
| RRAS | 2 | 2 | 1 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 0 |
| MRAS | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
| RIT | 2 | 2 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| DIRAS | 3 | 3 | 3 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
M: mammal; R/B: reptile/bird; X: xenopus; F: fish; Ci: ciona; Su: seaurchin; I: insect; W: worm; Fu: fungi; Mo: Monosiga; Sm: slime mold. In bold is highlighted the clades showing a duplication event compared with the parent clades. This table shows only gene sequences consistently classified into the different subgroups, where classification consistency is measured as a combination of bootstrapping value and domain composition. The total number of sequences in each species/clade is presented in Figure 3.