Table 2.
Number of Ras switch homologous genes detected in human, mouse, rat, zebrafish, fly and worm genomes
| Family | Subfamily | Gene | H | M | R | Z | F | W |
|---|---|---|---|---|---|---|---|---|
| Ras | RASL10 | RASL10A | 1 | 1 | 1 | 1 | 1 | 0 |
| RASL10B | 1 | 1 | 1 | 0 | ||||
| RASD | RASD1 | 1 | 1 | 1 | 1 | 1 | 0 | |
| RASD2 | 1 | 1 | 1 | 2 | ||||
| SSR2 | SSR2 | 0 | 0 | 0 | 2 | 2 | 1 | |
| NKIRAS | NKIRAS2 | 1 | 1 | 1 | 1 | 1 | 0 | |
| NKIRAS1 | 1 | 1 | 1 | 1 | ||||
| RGK | REM1 | 1 | 1 | 1 | 1 | 0 | 0 | |
| RRAD | 1 | 1 | 1 | 1 | ||||
| GEM | 1 | 1 | 1 | 1 | ||||
| REM2 | 1 | 1 | 1 | 1 | ||||
| RGK | 0 | 0 | 0 | 0 | 3 | 0 | ||
| RASL11 | RASL11A | 1 | 1 | 1 | 1 | 0 | 0 | |
| RASL11B | 1 | 1 | 1 | 1 | ||||
| RERG | RERG | 1 | 1 | 1 | 1 | 0 | 0 | |
| RASL12 | RASL12 | 1 | 1 | 1 | 1 | 0 | 0 | |
| RERGL | RERGL | 0 | 0 | 1 | 4 | 1 | 0 | |
| RHEB | RHEB | 1 | 1 | 0 | 1 | 1 | 0 | |
| RHEBL1 | 1 | 1 | 1 | 0 | 0 | 0 | ||
| ERAS | ERAS | 1 | 1 | 1 | 0 | 0 | 0 | |
| RAL | RALB | 1 | 1 | 1 | 2 | 1 | 1 | |
| RALA | 1 | 1 | 1 | 2 | ||||
| RAP1 | RAP1B | 2 | 1 | 1 | 1 | 1 | 1 | |
| RAP1A | 1 | 1 | 1 | 1 | ||||
| RAP2 | RAP2C | 1 | 1 | 1 | 1 | 1 | 1 | |
| RAP2A | 1 | 1 | 1 | 1 | ||||
| RAP2B | 1 | 1 | 1 | 1 | ||||
| H/K/NRAS | HRAS | 1 | 1 | 2/1 | 2 | 1 | 1 | |
| KRAS | 1 | 1 | 1 | 0 | ||||
| NRAS | 1 | 1 | 1 | 2 | ||||
| RRAS | RRAS2 | 1 | 1 | 1 | 1 | 1 | ||
| RRAS | 1 | 1 | 1 | 1 | 0 | |||
| MRAS | MRAS | 1 | 1 | 1 | 2 | 0 | 1 | |
| RIT | RIT2 | 1 | 1 | 1 | 0 | 1 | 0 | |
| RIT1 | 1 | 1 | 1 | 1 | ||||
| DIRAS | DIRAS2 | 1 | 1 | 1 | 2 | 1 | 1 | |
| DIRAS1 | 1 | 1 | 1 | 2 | ||||
| DIRAS3 | 1 | 0 | 0 | 0 | 0 | 0 | ||
| RapGAP | TSC2 | TSC2 | 1 | 1 | 1 | 0 | 1 | 0 |
| GARNL1 | C20ORF74 | 1 | 1 | 1 | 1 | 1 | 1 | |
| GARNL1 | 1 | 1 | 1 | 1 | ||||
| SIPA1 | SIPA1L3 | 1 | 1 | 0/1 | 1 | 0 | 1 | |
| SIPA1L1 | 1 | 1 | 1 | 1 | ||||
| SIPA1L2 | 1 | 1 | 1 | 1 | ||||
| SIPA1 | 1 | 1 | 1 | 1 | ||||
| RAP1GAP | GARNL4 | 1 | 1 | 1 | 2 | 1 | 1 | |
| RAP1GAP | 1 | 1 | 1 | 1 | 1 | |||
| GARNL3 | GARNL3 | 1 | 1 | 1 | 1 | 0 | 0 | |
| RasGAP | IQGAP | IQGAP1 | 1 | 1 | 1 | 1 | 0 | 0 |
| IQGAP2 | 1 | 1 | 0 | 1 | 0 | 0 | ||
| IQGAP3 | 1 | 1 | 1 | 0 | 0 | 0 | ||
| NF1 | NF1 | 1 | 1 | 1 | 2 | 1 | 0 | |
| RASA | RASA2 | 1 | 1 | 1 | 1 | 1 | 0 | |
| RASA3 | 1 | 1 | 1 | 1 | 0 | |||
| RASA4 | 2 | 1 | 1 | 1 | 0 | 0 | ||
| RASAL1 | 1 | 1 | 1 | 0 | 0 | 0 | ||
| SYNGAP | RASAL2 | 1 | 1 | 1 | 1 | 1 | 0 | |
| DAB2IP | 1 | 1 | 1 | 2 | ||||
| SYNGAP1 | 1 | 1 | 1 | 2 | ||||
| RASAL3 | 1 | 1 | 1 | 0 | ||||
| RASA1 | RASA1 | 1 | 1 | 1 | 2 | 1 | 0 | |
| GAPVD1 | GAPVD1 | 1 | 1 | 1 | 2 | 0 | 0 | |
| RasGEF | PLCE1 | PLCE1 | 1 | 1 | 1 | 0 | 0 | 0 |
| RASGRF | RASGRF2 | 1 | 1 | 1 | 1 | 0 | 0 | |
| RASGRF1 | 1 | 1 | 1 | 1 | ||||
| KNDC1 | KNDC1 | 1 | 1 | 0 | 1 | 0 | 0 | |
| RASGEF1 | RASGEF1A | 1 | 1 | 1 | 0 | 3 | 1 | |
| RASGEF1B | 1 | 1 | 1 | 2 | ||||
| RASGEF1C | 1 | 1 | 1 | 0 | ||||
| RAPGEF1 | RAPGEF1 | 1 | 1 | 0 | 1 | 1 | 1 | |
| RGL | RGL1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| RALGDS | 1 | 1 | 1 | 1 | ||||
| RGL3 | 1 | 1 | 1 | 2 | ||||
| RGL2 | 3/1 | 1 | 1 | 1 | ||||
| RGL4 | 1 | 0 | 0 | 0 | ||||
| RALGPS | RALGPS1 | 1 | 1 | 1 | 1 | 1 | 0 | |
| RALGPS2 | 1 | 1 | 1 | 1 | ||||
| RAPGEF2/6 | RAPGEF6 | 1 | 1 | 1 | 1 | 1 | 1 | |
| RAPGEF2 | 1 | 1 | 1 | 2 | ||||
| RAPGEF3/4 | RAPGEF4 | 1 | 1 | 1 | 3 | 1 | 1 | |
| RAPGEF3 | 1 | 1 | 1 | 1 | 0 | |||
| RAPGEF5 | RAPGEF5 | 1 | 1 | 1 | 2 | 0 | 0 | |
| RAPGEFL1 | RAPGEFL1 | 1 | 1 | 1 | 1 | 0 | 0 | |
| RASGRP | RASGRP3 | 1 | 1 | 1 | 1 | 0 | 1 | |
| RASGRP2 | 1 | 1 | 1 | 1 | ||||
| RASGRP1 | 1 | 1 | 1 | 1 | ||||
| RASGRP4 | 1 | 1 | 1 | 0 | ||||
| SOS | SOS2 | 1 | 1 | 1 | 1 | 1 | 1 | |
| SOS1 | 1 | 1 | 1 | 0 |
H: human; M: mouse; R: rat; Z: zebrafish; F: fly; W: worm. Cases with uncertain number of genes are indicated with ‘/’.