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. 2011 Mar 22;39(13):5682–5691. doi: 10.1093/nar/gkr155

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Mechanism of miR-423-5p-induced silencing of PR. (A) Methylation specific PCR of the PR promoter after treatment with miR-423-5p. U, unmethylated. M, methylated. (B) Bisulphite sequencing of the PR promoter following addition of miR-423-5p. Open circles, unmethylated CpG. Closed circles, methylated CpG. Circles represent individual CpG dinucleotides. (C) Timecourse of PR inhibition by miR-423-5p. miRNA mimics were added to cells at 25 nM.