Table 1.
Enumeration of CTCs and serum PSA concentrations in 19 patients with localized prostate cancer before and at serial intervals after resection of the primary tumor. The pathological features and standard markers of tumor invasiveness and prognosis are shown for each case, including analysis of the initial tumor biopsy (bx) and the fully resected pathological specimen (path). Evaluated parameters include Gleason score (GS; a measure of histological grade), prostate weight (in grams), pathologic stage (pTNM), percentage of gland infiltrated with cancer (% of Ca), presence of perineural invasion (PNI), and lymphatic vessel invasion (LVI). In all cases, surgical margins were negative. N/A, not available.
| CTCs/ml
|
Serum PSA
|
Pathology
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient no. | Before surgery | Day 1 | Day 9 | Day 50+ | Before surgery | Day 50+ | GS (bx) | GS (path) | Prostate weight | pTNM | % of Ca | PNI | LVI |
| 37 | 84 | 20 | N/A | N/A | 5.8 | <0.1 | 7 | 7 | 44.6 | T2cN0 | 15% | + | − |
| 38 | 109 | 34 | N/A | 8 | 2.8 | <0.1 | 6 | 6 | 40 | T2cNx | 5% | − | − |
| 39 | 197 | 2 | N/A | N/A | 6.8 | <0.1 | 6 | 7 | 48 | T2CNx | 25% | + | − |
| 40 | 106 | 2 | 0 | 1 | 5.8 | <0.1 | 7 | 7 | 56 | T2cN0 | 15% | + | − |
| 41 | 38 | 1 | 47 | 1 | 3.7 | <0.1 | 6 | 6 | 41 | T2bN0 | 3% | − | − |
| 42 | 45 | 23 | N/A | 196 | 4.3 | <0.1 | 7 | 7 | 56 | T2cN0 | 7% | + | − |
| 43 | 222 | 215 | 38 | 0 | 4.5 | <0.1 | 7 | 7 | 51 | T2cN0 | 15% | + | − |
| 44 | 57 | 157 | N/A | 20 | 5.5 | <0.1 | 9 | 9 | 42.6 | T3aN0 | 15% | + | − |
| 45 | 13 | 28 | 0 | 3 | 11.8 | <0.1 | 7 | 7 | 98 | T2aN0 | 1% | + | − |
| 46 | 2 | 1 | 25 | 5 | 2.2 | <0.01 | 6 | 6 | 31 | T2cNx | 5% | − | − |
| 47 | 2 | 315 | N/A | 0 | 9.8 | <0.1 | 9 | 9 | 58.5 | T3aN0 | 50% | + | + |
| 48 | 2 | 0 | 0 | 29 | 3 | <0.04 | 8 | 7 | 54 | T3aNx | <10% | + | − |
| 49 | 0 | 4 | 30 | 2 | 5.1 | <0.1 | 6 | 6 | 66 | T2Nx | 5% | + | − |
| 50 | 7 | 9 | 1 | 1 | 4.5 | <0.1 | 8 | 8 | 41.5 | T2cN0 | 15% | − | − |
| 51 | 2 | 2 | 8 | N/A | 7.4 | 0.1 | 7 | 7 | 32 | T3aN0 | 15% | + | − |
| 52 | 8 | 7 | 0 | 0 | 2.8 | <0.01 | 7 | 7 | 48.5 | T3aN0 | 5% | + | − |
| 53 | 4 | 4 | 3 | 5 | 3.9 | <0.1 | 6 | 6 | 51.9 | T2cNx | 5% | + | − |
| 54 | 8 | 1 | N/A | 0 | 3.4 | <0.1 | 6 | 6 | 40 | T2aNx | 5% | − | − |
| 55 | 6 | 3 | N/A | 2 | 1.5 | <0.1 | 7 | 7 | 17 | T2cN0 | 10% | + | − |