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. 2003 Dec 18;101(1):37–42. doi: 10.1073/pnas.0305080101

Table 1. Potency (Ki) of adenine nucleotides to inhibit crude and purified human sGC.

sGC Nucleotide Ki, μM
Vascular smooth muscle ATP 1,035 ± 121
8N3ATP ND
Purified human ATP 2,249 ± 475
8N3ATP 2,326 ± 1,064

Ki values were extracted from nonlinear regression analyses of the sigmoidal plots of the concentration-dependence analyses of ATP inhibition of sGC activated by 100 μM SNP (see Fig. 1) or 8N3ATP (see Fig. 2). Values are means ± SEM of three experiments performed in triplicate. ND, not determined.