Figure 1.

Intrathecal lidocaine pretreatment attenuated neurobehavioral responses to thermal and mechanical stimuli. (A) Mechanical responses. Comparison of mean paw withdrawal in response to a mechanical stimulus (F = 50 g; T = 20 seconds) between ipsilateral (left) and contralateral (right) sides in each group. Differences in mean paw withdrawal thresholds between hindpaws were significantly higher in Group L than in Group P on POD₃ (**P <0.01). (B) Hyperalgesic responses. On POD₃, the difference in mean withdrawal threshold between left and right hindpaws was significantly larger (☆P <0.001) in Group L than in Group P. Mean withdrawal thresholds did not significantly differ between left and right hindpaws in Group S. Data represent means ± SE.