Table 2.
Proportion of the asthma gene probes among probes differentially expressed during lung development in human and mouse data sets
| Human lungs | Mouse A/J lungs | Mouse SW lungs | Mouse C57BL6 lungs | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asthma probes | Asthma probes | Asthma probes | Asthma probes | |||||||||
| Differentially expressed | Yes | No | Total* | Yes | No | Total* | Yes | No | Total* | Yes | No | Total* |
| Yes | 71 | 11373 | 11444 | 25 | 3285 | 3310 | 15 | 2052 | 2067 | 32 | 6637 | 6669 |
| No | 149 | 29017 | 29166 | 64 | 8511 | 8575 | 71 | 9189 | 9260 | 110 | 32161 | 32271 |
| Total | 220 | 40390 | 40610 | 89 | 11796 | 11885 | 86 | 11241 | 11327 | 142 | 38798 | 38940 |
| % differentially expressed probes | 32 | 28 | 28 | 28 | 28 | 28 | 17 | 18 | 18 | 23 | 17 | 17 |
| p-value† | 0.18 | 1.0 | 1.0 | 0.09 | ||||||||
| OR (95% CI) | 1.22 (0.90-1.63) | 1.01 (0.61-1.63) | 0.95 (0.50-1.67) | 1.41 (0.92-2.11) | ||||||||
* Analyses restricted to probes represented by annotated genes.
† Fisher's exact test.
"Differentially expressed" refers to an adjusted p-value of <0.05 in the linear regression model.
OR = Odds ratio. CI = Confidence interval.