Table 3.
Gene expression analysis of specific asthma genes and evidence for differential expression during human lung development (adjusted p < 0.001 cut off)
| Human gene symbol | Probe id | Average expression | Adjusted p-value for differential expression | Beta coefficient† |
|---|---|---|---|---|
| NOD1 | 221073_s_at | 7.6 | 7.0E-8 | 0.012 |
| EDN1 | 222802_at | 9.3 | 1.6E-6 | 0.026 |
| EDN1 | 218995_s_at | 8.6 | 4.4E-6 | 0.019 |
| ROBO1 | 213194_at | 10.2 | 1.5E-5 | -0.009 |
| IL4R | 203233_at | 7.3 | 3.3E-5 | 0.010 |
| RORA | 226682_at | 8.2 | 3.5E-5 | 0.022 |
| RORA | 236266_at | 5.2 | 5.2E-5 | 0.011 |
| HPCAL1 | 212552_at | 9.4 | 5.4E-5 | 0.012 |
| HLA-DQB1 | 212998_x_at | 4.8 | 1.5E-4 | 0.012 |
| PLAUR | 210845_s_at | 5.9 | 2.0E-4 | -0.008 |
| IL2RB | 205291_at | 6.5 | 2.5E-4 | 0.007 |
| CCL5 | 204655_at | 4.7 | 2.6E-4 | 0.008 |
| HPCAL1 | 205462_s_at | 7.3 | 4.6E-4 | 0.013 |
| TLR10 | 223751_x_at | 4.1 | 4.9E-4 | 0.005 |
| PDE10A | 205501_at | 6.4 | 6.3E-4 | -0.011 |
| CCL5 | 1405_i_at | 4.1 | 9.9E-4 | 0.008 |
* Adjusted p-value (B-H method) for differential expression over time.
† The beta coefficient corresponds to the mean change in gene expression per day during the studied period (7-22 weeks of gestational age).