Table 3.
Riska of squamous cell carcinoma of the cervix for different human papillomavirus (HPV) types
| HPV type | HPV-positive | Age adjusted N = 203 cases & 309 controls |
Age and HIV adjusted N = 193 cases & 303 controls |
Age, HIV and CD4 adjusted N = 192 cases & 296 controls |
||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| High-risk HPV | ||||||||
| Allb | 183 | 54 | 64.5 | 35.4-126.6 | 84.7 | 43.5-181.6 | 82.3 | 42.2-176.8 |
| 16 | 101 | 10 | 29.1 | 15.4-60.7 | 28.8 | 15.2-60.2 | 27.2 | 14.4-56.9 |
| 18 | 39 | 8 | 9.6 | 4.6-22.3 | 8.9 | 4.2-20.6 | 8.3 | 4.0-19.2 |
| 31 | 2 | 3 | 0.8 | 0.1-4.6 | 0.7 | 0.1-3.7 | 0.5 | 0.1-2.8 |
| 33 | 4 | 5 | 1.3 | 0.3-4.7 | 1.2 | 0.3-4.4 | 1.4 | 0.3-5.6 |
| 35 | 10 | 7 | 2.4 | 0.9-6.7 | 2.5 | 0.9-6.9 | 2.7 | 1.0-8.1 |
| 39 | 3 | 1 | 3.7 | 0.6-38.9 | 4.2 | 0.7-44.4 | 4.2 | 0.7-44.2 |
| 45 | 18 | 0 | 58.7 | >7.9j | 56.5 | >7.6j | 57.2 | >7.7j |
| 51 | 2 | 8 | 0.8 | 0.2-2.7 | 0.5 | 0.1-2.1 | 0.5 | 0.1-2.1 |
| 52 | 6 | 13 | 0.7 | 0.2-1.7 | 0.6 | 0.2-1.5 | 0.5 | 0.2-1.3 |
| 56 | 2 | 4 | 0.9 | 0.2-4.6 | 1.0 | 0.2-4.7 | 1.1 | 0.2-5.5 |
| 58 | 2 | 3 | 0.9 | 0.2-5.1 | 1.0 | 0.2-5.8 | 1.1 | 0.2-5.8 |
| 59 | 1 | 2 | 0.7 | 0.1-6.5 | 0.8 | 0.1-7.4 | 0.8 | 0.1-7.4 |
| 68/73 | 6 | 7 | 1.5 | 0.5-4.6 | 1.3 | 0.4-4.0 | 1.3 | 0.4-3.9 |
| Low-risk HPV | ||||||||
| Allc | 5 | 24 | 0.5 | 0.2-1.0 | 0.3 | 0.1-0.8 | 0.3 | 0.1-0.7 |
| 6 | 1 | 3 | 1.0 | 0.1-7.0 | 1.1 | 0.1-8.0 | 1.1 | 0.1-7.9 |
| 11 | 0 | 2 | 0.5 | <6.4k | 0.4 | <5.4k | 0.3 | <4.3k |
| 34 | 0 | 1 | 0.6 | <11.1k | 0.4 | <7.5k | 0.3 | <5.3k |
| 40 | 0 | 1 | 0.7 | <13.0k | 0.8 | <14.7k | 0.8 | <14.6k |
| 42 | 1 | 0 | 4.1 | >0.2j | l | l | l | l |
| 44 | 0 | 4 | 0.2 | <2.2k | 0.3 | <2.5k | 0.2 | <2.5k |
| 53 | 0 | 4 | 0.1 | <1.2k | 0.1 | <1.2k | 0.1 | <1.1k |
| 54 | 1 | 3 | 0.4 | <2.5k | 0.4 | <2.8k | 0.5 | <2.9k |
| 66 | 0 | 5 | 0.4 | <2.2k | 0.1 | <1.0k | 0.1 | <1.1k |
| 70 | 1 | 3 | 0.7 | 0.1-4.2 | 0.6 | 0.1-3.7 | 0.5 | 0.1-3.2 |
| 74 | 2 | 4 | 1.0 | 0.1-4.2 | 0.9 | 0.2-4.6 | 0.8 | 0.1-3.8 |
| Single inf.d | 168 | 49 | 33.3 | 20.2-56.7 | 31.5 | 19.1-54.0 | 31.0 | 18.7-53.5 |
| Multiple inf.e | 15 | 20 | 1.3 | 0.7-2.7 | 1.2 | 0.6-2.4 | 1.1 | 0.5-2.3 |
| 16-relatedf | 123 | 36 | 11.6 | 7.5-18.5 | 11.9 | 7.6-19.0 | 11.4 | 7.2-18.3 |
| 18-relatedg | 66 | 16 | 9.4 | 5.3-17.4 | 8.9 | 5.0-16.5 | 8.6 | 4.9-16.1 |
| HPVXh | 3 | 26 | 0.2 | 0.1-0.5 | 0.2 | 0.1-0.5 | 0.2 | 0.1-0.6 |
| Any HPVi | 186 | 95 | 50.8 | 25.8-113.9 | 55.7 | 27.2-132.4 | 54.9 | 26.7-130.4 |
a OR and 95% CI.
b High-risk HPV: 16, 18, 31, 33, 35, 45, 51, 52, 56, 58, 59, 68/73.
c Low-risk HPV: 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 70, 74.
d Single infection: infection with any of the HPV types above, except HPVX.
e Multiple infections: infections with at least two different HPV types, except HPVX.
f HPV16-related: includes HPV16, 31, 33, 35, 52 and 58.
g HPV18-related: includes HPV18, 45, 59 and 68.
h HPVX: Samples which could not be typed with any of the 25 genotypes above.
i Any HPV infection: infection with any of the HPV types above.
j Indicate only lower limit value of 95% CI.
k Indicate only upper limit value of 95% CI.
l Could not be estimated due to lack of cases with known HIV status.
Abbreviations: inf: infections, OR: odds ratio, CI: confidence interval.