Table 5.
Risk of adenocarcinoma of the cervix for different human papillomavirus (HPV) typesa
| HPV type | Number HPV-positive | Age adjusted | Age and HIV adjusted | Age, HIV and CD4 adjusted | ||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| High-risk HPV | ||||||||
| Allb | 26 | 54 | 27.2 | 10.4-88.9 | 40.5 | 14.1-157.4 | 40.0 | 13.9-155.6 |
| 16 | 10 | 10 | 11.6 | 4.3-31.8 | 14.5 | 5.2-42.6 | 13.8 | 4.9-40.2 |
| 18 | 10 | 8 | 18.5 | 6.6-54.4 | 26.3 | 8.3-96.5 | 24.0 | 7.7-86.9 |
| 31 | 1 | 3 | 2.2 | 0.2-16.1 | 2.6 | 0.2-19.6 | 2.6 | 0.2-19.2 |
| 33 | 0 | 5 | 1.2 | <12.2j | 1.4 | <14.6j | 1.3 | <14.1j |
| 35 | 0 | 7 | 0.8 | <7.1j | 0.9 | <8.3j | 0.8 | <7.9j |
| 39 | 0 | 1 | 5.5 | <108.6j | 4.7 | <92.5j | 4.7 | <92.5j |
| 45 | 4 | 0 | 297.4 | >26.4k | 248.3 | >22.1k | 247.8 | >22.0k |
| 51 | 2 | 8 | 3.9 | 0.7-16.9 | 4.1 | 0.7-17.6 | 4.1 | 0.7-17.7 |
| 52 | 0 | 13 | 0.3 | <2.4j | 0.4 | <3.4j | 0.3 | <2.9j |
| 56 | 0 | 4 | 0.8 | <11.0 | 1.0 | <12.1j | 1.0 | <12.8j |
| 58 | 0 | 3 | 1.3 | <15.5j | 1.3 | <14.9j | 1.3 | <14.9j |
| 59 | 0 | 2 | 0.9 | <18.6j | 1.1 | <19.27j | 1.1 | <19.8j |
| 68/73 | 2 | 7 | 3.0 | 0.5-13.7 | 3.6 | 0.6-16.2 | 3.4 | 0.6-16.0 |
| Low-risk HPV | ||||||||
| Allc | 1 | 24 | 0.6 | 0.1-2.4 | 0.6 | 0.1-2.7 | 0.6 | 0.1-2.6 |
| 6 | 1 | 3 | 12.8 | 1.1-96.7 | 10.0 | 0.9-76.0 | 10.0 | 0.9-75.9 |
| 11 | 0 | 2 | 3.7 | <55.1j | 4.6 | <64.5j | 3.8 | <56.5j |
| 34 | 0 | 1 | 4.3 | <82.4j | 6.4 | <161j | 4.6 | <126.4j |
| 40 | 0 | 1 | 5.3 | <102.7j | 4.5 | <88.3j | 4.5 | <88.3j |
| 44 | 1 | 4 | 5.4 | 0.5-35.2 | 4.8 | 0.4-30.3 | 4.8 | 0.4-30.3 |
| 53 | 0 | 4 | 0.7 | <7.6j | 0.8 | <8.7j | 0.8 | <8.3j |
| 54 | 0 | 3 | 0.6 | <7.4j | 0.7 | <8.0j | 0.7 | <8.0j |
| 66 | 0 | 5 | 0.9 | <9.0j | 1.2 | <12.7j | 1.0 | <11.2j |
| 70 | 0 | 3 | 1.3 | <15.3j | 1.6 | <17.7j | 1.4 | <16.0j |
| 74 | 0 | 4 | 0.8 | <11.1j | 0.9 | <11.9j | 0.9 | <11.5j |
| Single inf.d | 22 | 49 | 13.7 | 6.0-34.0 | 15.5 | 6.6-40.5 | 15.3 | 6.5-40.0 |
| Multiple inf.e | 4 | 20 | 2.5 | 0.7-7.5 | 3.3 | 0.9-10.5 | 3.1 | 0.8-9.8 |
| 16-relatedf | 11 | 36 | 3.6 | 1.5-8.2 | 4.9 | 2.0-11.6 | 4.7 | 1.9-11.2 |
| 18-relatedg | 16 | 16 | 22.8 | 9.3-58.9 | 26.2 | 10.3-71.8 | 24.5 | 9.7-67.0 |
| HPVXh | 0 | 26 | 0.2 | <1.2b | 0.2 | <1.3b | 0.2 | <1.5b |
| Any HPVi | 26 | 95 | 12.9 | 5.0-41.8 | 18.7 | 6.6-71.6 | 18.6 | 6.6-71.2 |
a Analysis conducted with 32 cases and 309 controls.
b High-risk HPV: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73.
c Low-risk HPV: 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 70, 74.
d Single infection: infection with any of the HPV types above, except HPVX.
e Multiple infections: infections with at least two different HPV types, except HPVX.
f HPV16-related: includes HPV16, 31, 33, 35, 52 and 58.
g HPV18-related: includes HPV18, 45, 59 and 68.
h HPVX: Samples which could not be typed with any of the 25 genotypes above.
i Any HPV infection: infection with any of the HPV types above.
j Indicate only upper limit value of 95% CI.
k Indicate only lower limit value of 95% CI.
Abbreviations: inf: infections, OR: odds ratio, CI: confidence interval.