Table 7.
Odds ratios (OR) and 95% confidence intervals (CI) for squamous cell carcinoma and adenocarcinoma of the cervix according to HIV infection and adjustment factors: age, CD4 count (decrease of 100 cells), and human papillomavirus (HPV) types
Squamous cell carcinoma N = 246 cases, 308 controlsa |
Adenocarcinoma N = 39 cases, 308 controlsb |
|||
---|---|---|---|---|
Adjustment factor | OR for HIV-positive vs. HIV-negative | 95% CI | OR for HIV-positive vs. HIV-negative | 95% CI |
Age | 1.5 | 0.9-2.3 | 1.1 | 0.4-2.7 |
Age + CD4 | 1.6 | 1.0-2.6 | 0.8 | 0.1-2.6 |
Age + CD4 + HPV16 | 1.6 | 0.9-2.9 | 0.5 | 0.1-1.8 |
Age + CD4 + HPV16-relatedc | 1.4 | 0.7-2.4 | 0.5 | 0.1-1.6 |
Age + CD4 + HPV18 | 1.4 | 0.8-2.4 | 0.3 | <1.2j |
Age + CD4 + HPV18-relatedd | 1.4 | 0.8-2.4 | 0.4 | 0.1-1.5 |
Age + CD4 + High-risk HPVe | 0.6 | 0.3-1.1 | 0.3 | <0.9j |
Age + CD4 + Low-risk HPVf | 1.9 | 1.1-3.2 | 0.8 | 0.2-2.6 |
Age + CD4 + Single HPV inf.g | 1.2 | 0.6-2.4 | 0.5 | 0.1-1.7 |
Age + CD4 + Multiple HPV inf.h | 1.8 | 1.1-3.0 | 0.6 | 0.1-2.0 |
Age + CD4 + Any HPV inf.i | 0.8 | 0.4-1.4 | 0.4 | 0.1-1.2 |
a HIV-positive: 48 cases, 54 controls.
b HIV-positive: 5 cases, 54 controls.
c HPV16-related: includes HPV16, 31, 33, 35, 52 and 58.
d HPV18-related: includes HPV18, 45, 59 and 68.
e High-risk HPV: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73.
f Low-risk HPV: 6, 11, 34, 40, 42, 43, 44, 53, 54, 66, 70, 74.
g Single infection: infection with any of the HPV types above.
h Multiple infections: infections with at least two different HPV types.
i Any HPV infection: infection with any of the HPV types above.
j Indicate only lower limit value of 95% CI.
Abbreviations: inf: infections,.