Table 2.
Simple logistic regression to compare aspects of trial design, conduct and analysis by types of intervention, time before and after CONSORT (2001) and impact of journal
| Drug, % (n) | Non-drug, % (n) | Odds ratio (95% CI)(P-value) | From 2001, % (n) | Before 2001,% (n) | Odds ratio (95% CI) (P value) | Odds ratio (95% CI) (P value) per increase of 1 unit in impact factor | |
|---|---|---|---|---|---|---|---|
| Number of trials | 70 | 91 | - | 72 | 67 | - | 161 |
| Reporting of between- group comparisons | 90% (63) | 90% (82) | 0.98 (0.35 to 2.80) (0.98) | 96% (69) | 91% (61) | 2.26 (0.54 to 9.44) (0.26) | 1.03 (0.97 to 1.11) (0.32) |
| Primary outcome reported | 47% (33) | 20% (18) | 4.06 (2.02 to 8.14) (< 0.001) | 53% (38) | 21% (14) | 4.23 (2.00 to 8.95) (< 0.001) | 1.05 (1.02 to 1.09) (0.001) |
| Primary outcome is only one measure | 31% (22) | 13% (12) | 3.02 (1.37 to 6.65) (0.006) | 36% (26) | 12% (8) | 4.17 (1.73 to 10.06) (0.001) | 1.05 (1.02 to 1.08) (0.002) |
| No statistical comparison of baseline characteristics | 79% (55) | 60% (55) | 2.40 (1.18 to 4.88) (0.015) | 68% (49) | 70% (47) | 0.91 (0.44 to 1.86) (0.79) | 1.03 (1.00 to 1.08) (0.089) |
| Reporting of handling of missing data | 21% (15) | 14% (13) | 1.63 (0.72 to 3.71) (0.24) | 26% (19) | 13% (9) | 2.31 (0.96 to 5.55) (0.06) | 1.04 (1.01 to 1.07) (0.021) |
| Intention-to-treat analysis reported | 53% (37) | 33% (30) | 2.28 (1.20 to 4.33) (0.01) | 53% (38) | 39% (26) | 1.76 (0.90 to 3.46) (0.10) | 1.03 (1.00 to 1.06) (0.047) |
| Reporting of P values and 9% CI | 30% (21) | 19% (17) | 1.87 (0.89 to 3.89) (0.10) | 32% (23) | 22% (15) | 1.63 (0.76 to 3.47) (0.21) | 1.07 (1.04 to 1.11) (< 0.001) |