Table 1.
The ten most upregulated and down regulated primary epithelial genes in response to stroma, in 3D culture
| Gene Symbol | Gene Title | Fold change | Probe ID |
|---|---|---|---|
| FGFBP1 | fibroblast growth factor binding protein 1 | 3.078 | H300006842 |
| OR4N5 | olfactory receptor, family 4, subfamily N, member 5 | 2.993 | opHsV0400002653 |
| KLRC4 | killer cell lectin-like receptor subfamily C, member 4 | 2.735 | H300021805 |
| TESSP1 | testis serine protease 1 | 2.656 | opHsV0400002778 |
| KT3K | Ketosamine-3-kinase | 2.528 | H200004088 |
| KLRC1 | killer cell lectin-like receptor subfamily C, member 1 | 2.420 | H200005914 |
| SNX12 | sorting nexin 12 | 2.330 | H200009199 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 2.323 | H200014179 |
| DNMBP | Dynamin binding protein | 2.282 | opHsV0400003719 |
| MSH4 | mutS homolog 4 | 2.265 | H200011946 |
| IL23R | interleukin 23 receptor | -2.489 | H300020818 |
| DYNC2LI1 | dynein 2 light intermediate chain isoform 1 | -2.553 | opHsV0400000277 |
| KRT6B | keratin 6B | -2.560 | H300014335 |
| SAA1 | serum amyloid A1 | -2.600 | opHsV0400005893 |
| TOP1 | topoisomerase (DNA) I | -2.844 | opHsV0400006965 |
| PTPLAD1 | protein tyrosine phosphatase domain containing 1 | -2.859 | H300003447 |
| SEMA3C | sema domain, secreted 3C | -3.412 | H200008006 |
| KRT23 | keratin 23 | -3.552 | H300014341 |
| C3 | complement component 3 | -3.553 | H20000880 |
| MAGI1 | membrane associated guanylate kinase, WWW and PDZ domain containing 1 | -4.678 | H200002533 |
Values are the mean fold expression changes of ten primary epithelial cell cultures, abstracted from Operon datasets. All genes showed significant differential expression (p < 0.05). Positive values indicate up regulation, negative values indicate down regulation of epithelial genes cultured with stroma compared to without stroma. Hypothetical or unassigned genes were removed from the list.