Figure 5.
1H NMR spectra overlaid (4-fold) of the polar fraction of HepG2 cells exposed to DMSO (below) and TCDD (above). The following metabolites are identified by using standards, from the literature and/or databases and the numbers of the signals correspond to those indicated in Table 3. 1&2: leucine and isoleucine; 3: valine: 4: threonine: 5: lactale; 6: alanine; 7: putrescine; 8: acetate; 9: N-acetyl-aspartate; 10: glutamate; 11: glutamine; 12: reduced glutathione; 13: oxidized glutathione; 14: acetone; 15: citric acid; 16: creatine and/or phosphocreatine; 17: choline derivatives; 18: taurine; 19: glycine; 20: serine; 21: nucleotides derived from uridine (UMP, UDP, UTP); 22: nucleotides derived from adenosine (AMP, ADP, ATP); 23: NAD+ and/or NADH; 24: tyrosine; 25: formate.