Table 4.
Polar metabolites significantly affected by TCDD exposure.
| Metabolite | Change fold (1H NMR p < 0.01) | Change fold (LC-MS p < 0.01) |
|---|---|---|
| Leucine, Isoleucine | 0.69 | 0.64 |
| Valine | 0.72 | 0.69 |
| Alanine | 0.68 | -- |
| N-acetyl-aspartate | 0.68 | 0.72 |
| Glutamate | 0.79 | 0.80 |
| Glutamine | 0.69 | -- |
| Glycine | 0.72 | -- |
| Aspartate | 0.66 | -- |
| Serine | 0.65 | -- |
| Tyrosine | 0.58 | 0.44 |
| Proline | -- | 0.54 |
| Tryptophan | -- | 0.79 |
| Lactate | 0.49 | -- |
| Spermidine | -- | 0.24 |
| N1-acetyl-spermidine | -- | 0.59 |
| Pantothenic acid | -- | 0.62 |
| Creatine/Phosphocreatine | 0.66 | -- |
| Propyonylcarnitineb | -- | 0.66 |
| Butyrylcarnitine | -- | 0.58 |
| Nucleotides (AXP and UMP) | 0.3-0.6 | -- |
| UMP | -- | 0.71 |
| AMP | -- | 0.67 |
| Oxidized glutathione | 1.26 | 1.31 |
| Reduced glutathione | 1.58 | 1.23 |
| Taurine | 1.37 | -- |
| Citrate | 1.46 | 1.68 |
| UDP-N-acetyl-galactosamine/glucosamine* | -- | 1.48 |
The fold changes are given as the ratio of the average content in TCDD and in DMSO. Individual passage number results are in Additional File 1 (Tables S5 and S6).
*Tentatively identified