Fig. 2.

Antiinflammatory activity in the croton oil-induced ear inflammation model after topical application in mice and rats. Compounds were topically administered at doses from 0.3 to 300 μg/cm². In mice, 1 cm² and in rats, 2 cm² were treated. After 24 h, the ear weight, as a measure for edema, and peroxidase activity, as a parameter for granulocyte infiltration, were determined. Results are shown as percent inhibition (mean ± SD, n = 10) in comparison to solvent control group. *, P < 0.05 vs. solvent group in modified the Hemm test. #, P < 0.05 vs. PRED in the Mann-Whitney test.