Table 2. Effect on IL-8 secretion and TAT activity in cell lines.

	IL-8 inhibition IC50, nM	IL-8 inhibition efficacy, %	TAT induction EC50, nM	TAT induction efficacy, %
DEX.	2.6 ± 1	100	0.3	100
PRED	18 ± 12	92 ± 8	1.5	100
ZK 216348	35 ± 10	52 ± 15	95	88

Inhibition of IL-8 secretion in monocytic THP-1 cells as a parameter for transrepression and induction of TAT in hepatic H4-II-E-C3 cells as a transactivation parameter were determined for ZK 216348 in comparison to standard GCs. Efficacy is expressed relative to the maximal response to DEX. For IL-8 inhibition, mean ± SD values of three to five separate experiments are shown, whereas single values are given for TAT induction.