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| IL-12 p70 IC50, nM | IL-12 p70 efficacy, % | TNF-α IC50, nM | TNF-α efficacy, % | |
|---|---|---|---|---|
| DEX | 3.2 | 89 | 3.1 | 97 |
| PRED | 7.9 | 84 | 11 | 93 |
| ZK 216348 | 52 | 89 | 89 | 63 |
The effect of ZK 216348 on secretion of IL-12 p70 and TNF-α 24 h after LPS stimulation of human peripheral blood mononuclear cells was determined in comparison to the effect of standard GCs. Efficacy is expressed as absolute maximal inhibition of LPS-induced increase in cytokine release. Single values are shown.
