Table 3.
Functional analysis of EGF responsive pathways.
| ID | name | genes | regulated genes | connections | |
|---|---|---|---|---|---|
| 1 | 05200 | Pathways in cancer | 265 | 31 | 139 |
| 2 | 04510 | Focal adhesion | 156 | 17 | 97 |
| 3 | 04660 | T cell receptor signaling pathway | 80 | 7 | 69 |
| 4 | 05215 | Prostate cancer | 74 | 7 | 65 |
| 5 | 04662 | B cell receptor signaling pathway | 59 | 6 | 63 |
| 6 | 04010 | MAPK signaling pathway | 203 | 25 | 62 |
| 7 | 05210 | Colorectal cancer | 55 | 6 | 61 |
| 8 | 05222 | Small cell lung cancer | 76 | 12 | 60 |
| 9 | 04012 | ErbB signaling pathway | 74 | 9 | 60 |
| 10 | 04722 | Neurotrophin signaling pathway | 104 | 9 | 60 |
| 11 | 05220 | Chronic myeloid leukemia | 64 | 7 | 59 |
| 12 | 04810 | Regulation of actin cytoskeleton | 163 | 14 | 46 |
| 13 | 05214 | Glioma | 55 | 5 | 44 |
| 14 | 05211 | Renal cell carcinoma | 58 | 9 | 44 |
| 15 | 05223 | Non-small cell lung cancer | 51 | 6 | 42 |
| 16 | 05142 | Chagas disease | 71 | 5 | 41 |
| 17 | 04310 | Wnt signaling pathway | 118 | 7 | 41 |
| 18 | 05219 | Bladder cancer | 35 | 5 | 37 |
| 19 | 05140 | Leishmaniasis | 42 | 4 | 36 |
| 20 | 04620 | Toll-like receptor signaling pathway | 59 | 4 | 36 |
| 21 | 04912 | GnRH signaling pathway | 70 | 6 | 35 |
| 22 | 04210 | Apoptosis | 74 | 8 | 32 |
| 23 | 04916 | Melanogenesis | 76 | 3 | 30 |
| 24 | 04630 | Jak-STAT signaling pathway | 94 | 12 | 27 |
| 25 | 05410 | Hypertrophic cardiomyopathy (HCM) | 60 | 7 | 27 |
| 26 | 05414 | Dilated cardiomyopathy | 65 | 7 | 27 |
| 27 | 04115 | p53 signaling pathway | 58 | 11 | 25 |
| 28 | 04621 | NOD-like receptor signaling pathway | 40 | 6 | 25 |
| 29 | 05412 | Arrythmogenic right ventricular cardiomyopathy (ARVC) | 52 | 6 | 25 |
| 30 | 04920 | Adipocytokine signaling pathway | 55 | 6 | 24 |
| 31 | 04120 | Ubiquitin mediated proteolysis | 120 | 15 | 22 |
| 32 | 04370 | VEGF signaling pathway | 57 | 3 | 21 |
| 33 | 04060 | Cytokine-cytokine receptor interaction | 132 | 14 | 18 |
| 34 | 04640 | Hematopoietic cell lineage | 43 | 7 | 16 |
| 35 | 04530 | Tight junction | 97 | 7 | 16 |
| 36 | 04340 | Hedgehog signaling pathway | 39 | 3 | 15 |
| 37 | 04622 | RIG-I-like receptor signaling pathway | 46 | 4 | 15 |
| 38 | 04360 | Axon guidance | 105 | 9 | 14 |
| 39 | 05217 | Basal cell carcinoma | 41 | 1 | 12 |
| 40 | 04144 | Endocytosis | 162 | 13 | 11 |
| 41 | 05014 | Amyotrophic lateral sclerosis (ALS) | 41 | 3 | 8 |
| 42 | 04350 | TGF-beta signaling pathway | 69 | 6 | 6 |
| 43 | 00561 | Glycerolipid metabolism | 38 | 4 | 5 |
| 44 | 00564 | Glycerophospholipid metabolism | 59 | 4 | 5 |
| 45 | 00600 | Sphingolipid metabolism | 27 | 4 | 4 |
| 46 | 04070 | Phosphatidylinositol signaling system | 66 | 4 | 4 |
| 47 | 00562 | Inositol phosphate metabolism | 50 | 3 | 3 |
| 48 | 00565 | Ether lipid metabolism | 20 | 1 | 3 |
| 49 | 05020 | Prion diseases | 22 | 3 | 3 |
| 50 | 04710 | Circadian rhythm - mammal | 20 | 4 | 2 |
| 51 | 00601 | Glycosphingolipid biosysnthesis - lacto and neolacto series | 21 | 2 | 0 |
| 52 | 00532 | Glycosaminoglycan biosynthesis - chondroitin sulphate | 17 | 2 | 0 |
| 53 | 00760 | Nicotinate and nicotinamide metabolism | 17 | 4 | 0 |
| 54 | 00750 | Vitamin B6 metabolism | 5 | 1 | 0 |
| 55 | 00790 | Folate biosynthesis | 9 | 0 | 0 |
List of GlobalAncova derived differentially expressed KEGG functions upon EGF treatment indicating the total number of genes, the number of regulated genes and the number of connections (shared regulated genes) to other pathways. The number identifying each KEGG category are the same used for the nodes in the graph on Figure 7.