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. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255

Figure 3.

Figure 3

Cladribine induces apoptosis in MM cells. A, U266 cells were cultured with RPMI1640 (0.5% FBS) in the absence or presence of indicated concentrations of cladribine for 24 hrs. Cells were harvested and double-stained with Annexin V/PI, and then subjected to FACScan. The percentages of Annexin V-positive staining cells, indicative of apoptosis, were shown. B & C, RPMI8226 and MM1.S cells were cultured with RPMI1640 (0.5% FBS) in the absence or presence of indicated concentrations of cladribine for 24 hrs. Cells were collected and subjected to a specific apoptotic-ELISA. Bars, SD.