Figure 10.
Flow cytometric analysis of doxorubicin-sensitive and doxorubicin-resistant HuCC-T1 cells. HuCCT1 cells were exposed to doxorubicin or polymeric micelles (equivalent concentration of doxorubicin 1 μg/mL) for 1 hour. 1 × 106 cells were used for FACScan analysis. Doxorubicin-sensitive cells: (A) control, (B) doxorubicin, (C) polymeric micelles, (D) relative fluorescence intensity. Doxorubicin-resistant cells: (E) control; (F) doxorubicin; (G) polymeric micelles; (H) relative fluorescence intensity. The values were averaged over four separate experiments.
Notes: *P < 0.005; **P < 0.0001; ***P < 0.0001; ****P < 0.0001.