Table 4.
Pharmacokinetic parameters in rats after intravenous injection of PTX-NO and PTX-INJ (n = 6)
| Parameters | PTX-NO | PTX-INJ |
|---|---|---|
| α/h−1 | 4.177 ± 1.537a | 1.466 ± 0.366 |
| β/h−1 | 0.142 ± 0.049 | 0.204 ± 0.082 |
| VC, L · kg−1 | 0.748 ± 0.263 | 0.697 ± 0.271 |
| t1/2,α, hours | 0.1863 ± 0.077a | 0.495 ± 0.114 |
| t1/2,β, hours | 5.646 ± 2.941 | 3.774 ± 1.352 |
| AUC0–∞, μg · h · mL−1 | 5.196 ± 1.426b | 20.343 ± 9.119 |
| CL(s), L · kg−1 · h−1 | 2.050 ± 0.616a | 0.556 ± 0.190 |
| MRT, hours | 3.199 ± 3.718 | 2.753 ± 0.943 |
a
Notes: P < 0.05 vs PTX-INJ;
b
P < 0.01 vs PTX-INJ.
Abbreviations: AUC, area under concentration curve; CL, total plasma clearance; MRT, mean residence time; PTX-INJ, paclitaxel injection; PTX-NO, paclitaxel nanosuspension; t1/2,α, distribution half-life; t1/2,β, elimination half-life.