Table 5.

AUC values in various tissues after intravenous injection of PTX-NO and PTX-INJ into the mice

Tissue	AUC0–12 h (μg · g−1 · h)		rea
	PTX-NO	PTX-INJ
Heart	14.51 ± 6.21	18.02 ± 5.84	0.81
Liver	687.58 ± 117.56b	60.45 ± 20.49	11.37
Spleen	613.06 ± 218.34b	53.52 ± 29.55	11.45
Lung	104.48 ± 24.73b	43.92 ± 34.92	2.38
Kidney	21.91 ± 10.93	22.68 ± 9.47	0.97
Brain	9.48 ± 3.45	0.03 ± 0.03	294.27

^aNotes: r_e = AUC_PTX-NO/AUC_PTX-INJ;

^bP < 0.01 vs PTX-INJ.

Abbreviations: AUC, area under concentration curve; PTX-INJ, paclitaxel injection; PTX-NO, paclitaxel nanosuspension.