TABLE 5.
Theoretical and estimated parameters for the agonist concentration-response curves shown in Fig. 6
| Agonist | Theoretical Parameters |
Estimated Parameters |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Log Ka | Log Kb | Log Kb/Kb′ | Log Kobsa | Relative Efficacyb | Log Ka | Log RIic | Log RAic | Log Kobs | Relative τd | |
| A | 5.0 | 10.48 | 4.0 | 6.74 | 1.00 | 4.43 | −0.52 | 4.06 | N.D. | 1.00 |
| B | 5.0 | 9.48 | 3.0 | 5.81 | 0.86 | 4.98 | 0.025 | 3.07 | N.D. | 0.86 |
| C | 5.0 | 8.48 | 2.0 | 5.19 | 0.36 | 4.99 | 0.038 | 2.07 | N.D. | 0.37 |
| D | 5.0 | 8.0 | 1.52 | 5.08 | 0.16 | 5.00 | 0.050 | 1.59 | 5.08 | 0.15 |
| E | 5.0 | 7.48 | 1.0 | 5.02 | 0.053 | 5.00 | 0.043 | 1.09 | 5.02 | 0.054 |
| F | 5.0 | 7.0 | 0.52 | 5.01 | 0.018 | 4.99 | 0.038 | 0.60 | 5.00 | 0.019 |
| G | 5.0 | 6.48 | 0 | 5.00 | 0.0056 | 4.95 | 0.00 | 0.00 | 4.96 | 0.0058 |
N.D., not determined.
a
Represents the log reciprocal of the agonist concentration required for half-maximal formation of the DRs*GX complex.
b
Represents the maximal amount of DRs*GX complex formed by the agonist, expressed relative to that of agonist A.
c
Expressed relative to that of agonist G.
d
Expressed relative to that of agonist A.