. 2011 Aug;338(2):671–686. doi: 10.1124/jpet.111.179309

TABLE 2.

Estimation of K_b, K_obs, and relative efficacy using equations 57, 58, and 59, respectively

The parameters were estimated from the T_sat and EC₅₀ values of the concentration-response curves shown in Fig. 4. For the calculations, it was assumed that the T_sat of agonist A was a good estimate of M_sys. The estimate of the basal response was 20.6%.

Agonist	T_sat	Log EC₅₀	Log K_b	Log K_obs	Log Relative Efficacy^a
	% M_sys
A	100	−7.32	8.00	N.D.	N.D.
B	96.6	−6.33	7.00	4.97	0.00
C	73.4	−5.46	6.02	4.99	−1.01
D	34.0	−5.08	5.37	5.07	−1.74
E	13.5	−6.96	6.72	6.95	−2.26
F	5.05	−6.92	6.32	7.01	−2.72
G	0.28	−6.90	5.03	6.99	−4.00

N.D., not determined.

Expressed relative to that of agonist B.