TABLE 1.
Potency of CsA analogs against the IL-2 reporter assay and HUVEC proliferation
For CsA and N-Me-Val-4-CsA, n = 3 for proliferation and n = 4 and 5, respectively, for the IL-2 reporter. The parenthetical values are 95% confidence intervals. For all other analogs, experiments were conducted in duplicate and parenthetical values are S.E.M.
| Compound | IL-2 Reporter IC50 | HUVEC Proliferation IC50 |
|---|---|---|
| nM | μM | |
| CsA | 1.22 (0.37, 4.03) | 2.62 (1.87, 3.65) |
| N-MeVal-4-CsA | >10,000 | 3.95 (2.97, 5.26) |
| 1 | 53.9 (22.9) | 1.17 (0.24) |
| 2 | 107 (12.1) | 3.38 (3.17) |
| 3 | 40.4 (26.3) | 3.34 (0.94) |
| 4 | 12.9 (6.51) | 2.71 (1.42) |
| 5 | 34.2 (23.2) | 7.28 (0.92) |
| 6 | 116 (86.6) | 5.49 (3.08) |