TABLE 2.
Comparison of the Ki for CsA and N-MeVal-4-CsA against eight human cyclophilins
| Enzyme | Alias/Gene Name | KiN-MeVal-4-CsA | Ki CsAa |
|---|---|---|---|
| nM | |||
| CypA | Cyp18/PPIA | 7.2 ± 2.0 | 2.9 |
| CypB | Cyp23/PPIB | 9.7 ± 1.8 | 8.4 |
| CypC | Cyp23a/PPIC | 25.1 ± 8.8 | 7.7 |
| Cyp40 | PPID | 72.7 ± 13.7 | 319 ± 76 |
| CypD | Cyp22/PPIF | 39.6 ± 7.5 | 6.7 |
| USA-Cyp | Cyp19.2/PPIH | 293 ± 40 | 91 |
| CypJ | Cyp18.1/PPIL3 | 900 ± 800 | N.D. |
| Cyp33 | PPIE | 147.0 ± 21 | N.D. |
N.D., not determined.
a
Ki values for inhibition by CsA of CypA, CypB, CypC, PPIL1, and USA-Cyp were taken from Daum et al. (2009).