TABLE 2.

Effects of acute treatment with PDE4 inhibitors on immobility in the forced-swim test

Values shown are means ± S.E. for times of immobility of separate groups of rats tested in the forced-swim test; n = 6 per group. Rats were treated with PDE4 inhibitors and tested in forced-swim test 0.5 or 2 h post-treatment.

	Immobility
	0.5 h Post-Treatment	2 h Post-Treatment
	s
Vehicle	154 ± 10.2	138 ± 14.2
Rolipram	84 ± 12.1*	144 ± 7.4
0.3 mg/kg	174 ± 9.2	122 ± 7.0
1 mg/kg
3 mg/kg	201 ± 8.6	127 ± 10.9
Piclamilast	58 ± 6.24**	132 ± 5.9
0.3 mg/kg
1 mg/kg
3 mg/kg	129 ± 25.4	123 ± 9.3
CDP840	91 ± 6.5*	141 ± 10.6
3 mg/kg	122 ± 19.0	126 ± 12.5
10 mg/kg
30 mg/kg	125 ± 15.0	123 ± 6.1

^**P < 0.01; *P < 0.05 vs. corresponding control.